#Definition of scaffold how to#

An investigation of the degree to which it is possible to formulate a more rigorous definition of scaffolds and hopping in the context of molecular topologies is considered. In this paper, the current statuses of scaffolds and scaffold hopping are reviewed based on published examples of scaffold hopping from the literature.

#Definition of scaffold how to#

However, this leaves the paradox of how to describe both scaffold similarity and dissimilarity simultaneously. In the latter, the scaffolds must permit a similar geometric arrangement of functional groups to permit the mode of action. The teacher then gradually steps back and lets students practice on their own. In the instructional scaffolding model, a teacher may share new information or demonstrate how to solve a problem. Essentially, it is agreed that scaffolds should be substantially different from each other, although significantly similar to each other, to constitute a hop. Scaffolding refers to a method where teachers offer a particular kind of support to students as they learn and develop a new concept or skill.

It follows, therefore, that the definition of scaffold hopping and, more importantly, the detection of what constitutes a scaffold hop, is also ill-defined and highly subjective. However, this is far from the case with the definition of a scaffold being highly dependent on the particular viewpoint of a given scientist. Title: On Scaffolds and Hopping in Medicinal ChemistryĪbstract: The molecular scaffold is an oft-cited concept in medicinal chemistry suggesting that the definition of what makes a scaffold is rigorous and objective. Keywords: Scaffold, scaffold hopping, markush, isofunctional, lead hopping, chemoinformatics These techniques are adapted from chemoinformatics to be applied in the design of new medicinal compounds. Essentially, it is agreed that scaffolds should be substantially different from each other, although significantly similar to each other, to constitute a hop. The molecular scaffold is an oft-cited concept in medicinal chemistry suggesting that the definition of what makes a scaffold is rigorous and objective.